It is no longer tenable to attribute all the antipsychotic action of antipsychotic drugs to dopamine da d2 receptor blockade and subsequent development of depolarization inactivation of the mesolimbic or mesocortical da neurons the chief evidence for this position is that clozapine cloz does no the mechanism of action of novel antipsychotic drugs schizophr bull 1991172263 87 doi . Such findings underpin the application of drugs which activate the nmda receptors as possible novel antipsychotics thus glycine and d serine as nmda receptor agonists have been studied for their potential antipsychotic effects high doses of glycine 30 60 g day have been shown to improve the negative symptoms in schizophrenia d serine a full agonist at the nmda receptor glycine site . Title novel antipsychotic drug carriers the development of nanoparticle and microgel drug carriers for antipsychotic delivery in the treatment of schizophrenia author justin e piazza hbsc mcmaster university supervisor dr ram k mishra number of pages xx 136 iii abstract lectin functionalized poly oligoethylene glycol methyl ether methacrylate poegma loaded with 3r 2 . Moreover zito and associates found that antipsychotics were the most commonly prescribed class of drugs for children and adolescents treated as psychiatric inpatients and that the drugs were prescribed for disorders other than schizophrenia in 1989 the novel atypical antipsychotic clozapine was marketed for the treatment of schizophrenia
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